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KMID : 0381120210430111361
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Genes and Genomics
2021 Volume.43 No. 11 p.1361 ~ p.1369
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HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway
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Zhang Juan
Chang Yuhan
Xia Haiyan
Xu Luwei
Wei Xiaowei
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Abstract
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Background: The potential role of HIST1H2BN in prostate cancer remains unclear.
Objective: To evaluate the carcinogenic role of HIST1H2BN in prostate cancer.
Methods: The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells.
Results: HIST1H2BN was significantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then influenced the expression of MMP2 and MMP9.
Conclusion: This is the first study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer.
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KEYWORD
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HIST1H2BN, EMT, NF-κB, Prostate cancer
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